Journal of the Chemical Society. Perkin transactions II p. 373 - 379 (1980)
Update date:2022-08-05
Topics:
Lazarus, Robert A.
Benkovic, Patricia A.
Benkovic, Stephen J.
Intramolecular displacement reactions at phosphorus have been examined in a series of N-alkyl-O-arylphosphorylethanolamines in water at 35 deg C.The examination of the pH-rate profiles and the direct observation by 31P n.m.r. of the reaction products implicate a nucleophilic role for the amine.A rate enhancement of 1E6-1E7 is observed.Structure-reactivity correlations derived by changing the pKa of the amine and leaving group yield values for βnuc<*> 0.7 and βlg<*> -1.25 and support an uncoupled concerted mechanism.A discussion of the mechanisms of nucleophilic reactions involving amines and oxyanions with inter- and intra-molecular phosphate di- and tri-esters is presented.
View MoreFeis International Trade Co,. Ltd
Contact:13961823444-18235944442
Address:Wuxi jiangsu
NINGBO PANGS CHEM INT’L CO., LTD.
Contact:+86-0574-27666801
Address:Floor 21, Building 11, Xintiandi, No. 689, Shijiroad, Ningbo, Zhejiang, China
website:http://www.eastarchem.com/
Contact:1-800-898-2436
Address:1215 K Street, STE 1700
Contact:+86-134-5286-9121
Address:Add: Wing Tuck Commercial Centre, 177-183 Wing Lok Street, Hong Kong,
Guangxi Nanning Guangtai Agriculture Chemical Co.,Ltd
Contact:+86-771-2311266
Address:Room703,Building12, Software Park Phase II,NO.68,Keyuan Road,Nanning City,Guangxi,China
Doi:10.1039/b404425h
(2004)Doi:10.1016/j.bmc.2004.05.038
(2004)Doi:10.1002/chem.201504515
(2016)Doi:10.1055/s-1997-739
(1997)Doi:10.1021/jm049968m
(2004)Doi:10.1002/hlca.200490096
(2004)
