Journal of Pharmaceutical Sciences p. 477 - 480 (1980)
Update date:2022-08-03
Topics:
Foye
Kauffman
Reaction of 1-methylquinolinium-2-dithioacetic acid zwitterions with excess methyl iodide in dimethylformamide gave the corresponding bis(2-methylthio)vinyl derivatives. These compounds were more soluble in both aqueous and organic media than the dithioacetic acid zwitterions but showed comparable antileukemic activity in mice. Reaction with morpholine converted a bis(2-methylthio)vinyl derivative almost quantitatively to the 2-mono(methylthio)-2-morpholino derivative. Leukemia cell culture studies of the 6-methyl derivative showed no effect on cell cycle processes.
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Doi:10.1055/s-1999-3429
(1999)Doi:10.1007/BF00777383
(1980)Doi:10.1039/c9cc06652g
(2019)Doi:10.1002/jhet.5570170120
(1980)Doi:10.1021/ol900125y
(2009)Doi:10.1016/0040-4039(90)80206-2
(1990)
