Carbon-Carbon Bond Formation by the Use of Chloroiodomethane as a C1 Unit. IV. The Mannich Reaction of Ketones by Means of Dihalomethane and Secondary Amine

Article abstract of DOI:10.1246/bcsj.55.1331

Treatment of ketones with dihalomethane (CH2Br2, CH2ClI, and CH2I2) in the presence of secondary amine, preferably pyrrolidine, gave the corresponding Mannich base in varing yields depending on the substrate and/or combination of the reagents.