Pyridopyrimidines. 11. Synthesis of 5-Deaza-5-oxoaminopterin and Related Compounds

Article abstract of DOI:10.1021/jo01307a004

The syntheses of 5-deaza-5-oxo analogues of aminopterin, methotrexate, and 10-thiaaminopterin are described.The sequence involves, as a key step, the preparation of 2,4-diamino-6-(hydroxymethyl)-5-oxopyrido<2,3-d>pyrimidine from readily accessible pyridopyrimidine derivatives.