Journal of Organic Chemistry p. 3746 - 3748 (1980)
Update date:2022-07-29
Topics:
Srinivasan, Ananthachari
Broom, Arthur D.
The syntheses of 5-deaza-5-oxo analogues of aminopterin, methotrexate, and 10-thiaaminopterin are described.The sequence involves, as a key step, the preparation of 2,4-diamino-6-(hydroxymethyl)-5-oxopyrido<2,3-d>pyrimidine from readily accessible pyridopyrimidine derivatives.
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(1965)Doi:10.1107/S0567740880007352
(1980)Doi:10.1016/0040-4020(80)80006-8
(1980)Doi:10.1016/0040-4020(82)85049-7
(1982)Doi:10.1002/jps.2600560729
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(1981)
