Fluorinated Analogues of 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea: An Attempt to Control Metabolism

DOI: 10.1021/jm00185a015

Source and publish data:

Journal of Medicinal Chemistry p. 1226 - 1229 (1980)

Update date:2022-07-30

Topics:

Authors:

Foster, Allan B.

Jarman, Michael

Coe, Paul L.

Sleigh, John

Tatlow, J. Colin

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Article abstract of DOI:10.1021/jm00185a015

In seeking to block and thereby determine the role of the rapid in vivo hydroxylation of the cyclohexyl moiety of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) in relation to antitumor activity and tissue distribution, the 3-(1H-decafluorocyclohexyl

Full text of DOI:10.1021/jm00185a015

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