Synthesis and antiviral activity of 1-(2-deoxy-β-D-ribofuranosyl)-5-(methylmercapto)-2-pyrimidinone

DOI: 10.1021/jm00133a022

Source and publish data:

Journal of Medicinal Chemistry p. 109 - 112 (1981)

Update date:2022-08-02

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Authors:

Schroeder

Bardos Bardos

Cheng Cheng

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Article abstract of DOI:10.1021/jm00133a022

1-(2-Deoxy-β-D-ribofuranosyl)-5-(methylmercapto)-2-pyrimidinone (1b) was synthesized via modification of the silyl method. 1b inhibits the Herpes simplex virus type 1 (98%) and type 2 (97%) at a concentration which is nontoxic to human HeLa cells. The com

Full text of DOI:10.1021/jm00133a022

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