
Heterocyclic Communications p. 281 - 286 (2002)
Update date:2022-08-04
Topics:
Prasad, Chalasani S.N.
Varala, Ravi
Adapa, Srinivas R.
This report describes an improved synthesis of a heterocyclic propionic acid, 2-4(1-oxo-2-isoindolinyl) phenyl propionic acid, Indoprofen (I) via carbonylation, a potent anti-inflammatory agent1 and an analgesic. The synthesis highlights the preparation of Indoprofen starting from readily available o-toluic acid and p-amino acetophenone by a sequence of reactions that included oxidative addition of carbonylation.
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