Asymmetric Synthesis of (2R,6R) and (2S,6S)-2,6-Dimethylpiperazine

Article abstract of DOI:10.1016/0957-4166(94)00341-8

The title compounds were prepared via two efficient routes.The first sequence utilized a diastereospecific triflate alkylation in the key bond forming step while the second method relied on a novel intramolecular Mitsunobu reaction to set the required stereochemistry.