Chemistry Letters p. 737 - 740 (1981)
Update date:2022-08-04
Topics:
Matsueda, Rei
Kimura, Takahide
Kaiser, Emil Thomas
Matsueda, Gary R.
The use of the 3-nitro-2-pyridinesulfenyl (Npys) halide, a versatile reagent in peptide chemistry, for the protection and activation of the thiol function is reported.Boc-Cys(Npys)-OH is prepared starting from bis(N-t-butyloxycarbonyl)-L-cystine.The Npys group is easily removed by treatment with a stoichiometric amount of tri-n-butylphosphine in the presence of water, but it is resistant to acids such as trifluoroacetic acid, HCl, and HF.Importantly, the cysteine residue modified with the Npys group can react selectively with free thiol of cysteine to afford a cystine disulfide bond.
View MoreReliable Pharma Technology (Shanghai) Co., Ltd.
Contact:0086-21-67676847-8008
Address:Lane 1500, No.68, Xinfei Road, Songjiang District, Shanghai, 201611, P.R.China.
Contact:0512-63006287
Address:no.88.YISHENG Road,etdz-WUJIANG,SUZHOU,CHINA
Contact:86-513-84128750/13773795976
Address:No.48.Youyi West Road ,Rudong Development Zone,Jiangsu Province,China
website:http://www.apeptides.com/en/
Contact:+86-21-60871011
Address:No. 80 Chuanshan Shuyuan Steet,Pudong,Shanghai
Contact:+86-519-8525-2752
Address:Changzhou
Doi:10.1002/adsc.201800614
(2018)Doi:10.1002/jps.2600700111
(1981)Doi:10.1021/jm00137a012
(1981)Doi:10.1016/0040-4020(80)80225-0
(1980)Doi:10.1016/0040-4039(78)80026-4
(1978)Doi:10.1080/07328303.2015.1105249
(2015)
