Discovery of triazolinone non-nucleoside inhibitors of HIV reverse transcriptase

DOI: 10.1016/j.bmcl.2008.06.080

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 4348 - 4351 (2008)

Update date:2022-07-30

Topics:

Authors:

Sweeney, Zachary K.

Acharya, Sahaja

Briggs, Andrew

Dunn, James P.

Elworthy, Todd R.

Fretland, Jennifer

Giannetti, Anthony M.

Heilek, Gabrielle

Li, Yu Li, Yu

Kaiser, Ann C.

Martin, Michael

Saito, Y. David

Smith, Mark

Suh, Judy M.

Swallow, Steven

Wu, Jeffrey

Hang, Julie Q.

Zhou, Amy S.

Klumpp, Klaus

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Article abstract of DOI:10.1016/j.bmcl.2008.06.080

Novel non-nucleoside inhibitors of HIV-RT that contain pyridazinone isosteres were prepared, and a series of triazolinones were found to be potent inhibitors of HIV replication. These compounds were active against several NNRTI-resistant virus strains. Ph

Full text of DOI:10.1016/j.bmcl.2008.06.080

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