Journal of Medicinal Chemistry p. 496 - 499 (1981)
Update date:2022-08-02
Topics:
Itzhak, Yossef
Kalir, Asher
Weissman, Ben Avi
Cohen, Sasson
Several esters of 1-(1-phenylcyclohexyl)-4-piperidinol (3), 1-(1-phenylcyclohexyl)-4-phenyl-4-piperidinol (10) and its propionate (11), and 1-(1-phenylcyclohexyl)-4-phenylpiperidine (13) were prepared and characterized.The new compounds, which are derived from phencyclidine, exerted analgesic activity in mice.The most potent is 10, which is twice as active as morphine.The antinociceptive activity of 10, 11, and 13 could be well correlated with their potency in the mouse vas deferens bioassay, and both were completely reversed by naloxone.
View Morewebsite:http://www.tcfinechem.com/
Contact:18681346930
Address:baifu town,whou district
Hangzhou Hysen Pharma co.,Ltd.
website:http://www.hysenpharma.cn/
Contact:0086-571-88298791
Address:#701,Gudun Road Hangzhou
Shanghai Harvest Chemical Ind. Co., Ltd.
Contact:021-51385350
Address:ROOM 806-807, AI LI CHEN BUILDING, No.333 JINGXIANG ROAD, PUDONG DISTRICT, 201206, SHANGHAI
Contact:+852 83038667
Address:Room 1502, 15th Floor, SPA Centre,53-55 Lockhart Road, Wanchai, Hong Kong
Hangzhou Neway Chemicals Co., Ltd.
Contact:+86-571-85095566
Address:Room 803, Qinglian Bldg, No 139 Qingchun Road, Hangzhou, Zhejiang China
Doi:10.1021/je00025a037
(1981)Doi:10.1016/S0040-4020(01)80525-1
(1993)Doi:10.1134/S1070363207050143
(2007)Doi:10.1081/NCN-120030722
(2004)Doi:10.1021/jo049047j
(2004)Doi:10.1016/j.tetasy.2004.06.043
(2004)
