Journal of Medicinal Chemistry p. 496 - 499 (1981)
Update date:2022-08-02
Topics:
Itzhak, Yossef
Kalir, Asher
Weissman, Ben Avi
Cohen, Sasson
Several esters of 1-(1-phenylcyclohexyl)-4-piperidinol (3), 1-(1-phenylcyclohexyl)-4-phenyl-4-piperidinol (10) and its propionate (11), and 1-(1-phenylcyclohexyl)-4-phenylpiperidine (13) were prepared and characterized.The new compounds, which are derived from phencyclidine, exerted analgesic activity in mice.The most potent is 10, which is twice as active as morphine.The antinociceptive activity of 10, 11, and 13 could be well correlated with their potency in the mouse vas deferens bioassay, and both were completely reversed by naloxone.
View MoreHuangshi Meifeng Chemical Co.,ltd.
Contact:+86-714-6516706
Address:1941-4-3#,Hubin Avenue,Huangshi,Hubei,China
Contact:+86-570-4336358
Address:No.87 Building,Tianqian,Sidu Town
Jinhua City Mingzhu Pharmaceutical Co.,Ltd.
Contact:15857995878 0579-82207761
Address:No.169 Shenze Road, New Area,Jinpan Development Zone, Jinhua
HANGZHOU ZHONGCHANG SCIENTIFIC CO.,LTD
Contact:+86-571-88932183
Address:Hangzhou
Contact:+86-158-05817090
Address:ROOM 9F, FLAT 2, GUODU DEVELOPING BLDG, No.182, ZHAOHUI ROAD
Doi:10.1021/je00025a037
(1981)Doi:10.1016/S0040-4020(01)80525-1
(1993)Doi:10.1134/S1070363207050143
(2007)Doi:10.1081/NCN-120030722
(2004)Doi:10.1021/jo049047j
(2004)Doi:10.1016/j.tetasy.2004.06.043
(2004)
