A Palladium-Catalyzed Construction of Enantiomerically Pure α-Methylene-γ-butyrolactones. Enantiospecific Synthesis of Both Enantiomers of Methylenolactocin

Article abstract of DOI:10.1016/0957-4166(95)00096-8

Optically active β,γ-disubstituted-α-methylene-γ-butyrolactones were synthesized by palladium(II)-catalyzed cyclization reactions of homochiral allylic 2-alkynoates.The reaction was applied to the total synthesis of methylenolactocin in both enantiomeric