NEO-CLERODANE DITERPENOIDS FROM TEUCRIUM POLIUM SUBSP. CAPITATUM

Article abstract of DOI:10.1016/S0031-9422(00)94525-4

From the arial part of Teucrium polium subsp. capitatum three new neo-clerodane diterpenoids, 7-deacetylcapitatin, picropolinol and 20-epi-isoeriocephalin, have been isolated, together with the previously known diterpenes picropolin, picropolinone, 19-acetylgnaphalin and teucjaponin B.The structures of 7-deacetylcapitatin <19-acetoxy-4α,18:15,16-diepoxy-7α-hydroxy-6-keto-neo-cleroda-13(16),14-dien-20,12S-olide>, picropolinol <18,19-diacetoxy-15,16-epoxy-4α,6α-dihydroxy-7-keto-neo-cleroda-13(16),14-dien-20,12S-olide> and 20-epi-isoeriocephalin <19-acetoxy-4α,18:15,16-diepoxy-6α-hydroxy-7-keto-neo-cleroda-13(16),14-diene-(20-O-acetyl)-20R,12S-hemiacetal> were established by chemical and spectroscopic means and, in the case of 7-deacetylcapitatin and picropolinol, by correlation with known compounds.Key Word Index-Teucrium polium subsp. capitatum; Labiatae; diterpenoids; new neo-clerodane derivatives; 7-deacetylcapitatin; picropolinol; 20-epi-isoeriocephalin.