Regio- and chemoselective conjugate 1,4-reduction of α-oxoketene dithioacetals with sodium borohydride and sodium cyanoborohydride

Article abstract of DOI:10.1016/S0040-4020(01)89784-2

Theα-oxoketene dithioacetals 1 are shown to undergo conjugate 1,4-reduction in highly regio- and chemoselective manner with sodium borohydride in acetic acid to afford the corresponding β-oxodithioacetals 5 in good yields. These results have been rational