Synthesis of Spiro as Potential Central Nervous System Agents. 6. Synthesis, 13C NMR, and Biological Evaluation of cis-and trans-4-Amino-3'-arylspiro Derivatives

DOI: 10.1021/jm00137a025

Source and publish data:

Journal of Medicinal Chemistry p. 617 - 621 (1981)

Update date:2022-08-04

Topics:

Authors:

Martin, Lawrence L.

Worm, Manfred

Agnew, Marc N.

Kruse, Hansjoerg

Wilker, Jeffrey C.

Geyer, Harry M.

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Article abstract of DOI:10.1021/jm00137a025

4-(Dimethylamino)- and 4-(methylamino)-3'-arylspiro derivatives were prepared as analogues of previously reported 3-arylspiro.Metalation of benzanilide with n-butyllithium, addition

Full text of DOI:10.1021/jm00137a025

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