Journal of Medicinal Chemistry p. 1063 - 1067 (1981)
Update date:2022-08-02
Topics:
Stokker, G. E.
Deana, A. A.
deSolms, S. J.
Schultz, E. M.
Smith, R. L.
et al.
A series of modified 2-(aminomethyl)phenols was synthesized and tested orally in rats for saluretic and diuretic effects.Intravenous dog data are included as supplementary material to show that the diuretic responses, or lack thereof, may be obtained in a second species.Reorientation of the 2-(aminomethyl) group either meta or para to the hydroxyl substituent resulted in loss of diuretic effects.Similarly, replacement of either the phenolic hydroxyl or the aminomethyl group with other functional moieties substantially diminished saluretic effects.
View MoreJining Shengrun Chemical Industry Co., Ltd.
Contact:+86-537-7121666 ,
Address:West Ring Road,Wenshang County Shandong Province
Contact:--
Address:80G, No.1 Building, Guodu Development Mansion, No. 182 Zhaohui Road, Hangzhou City, Zhejiang Province,China.
Huaian Double Win Chemicals Co.,Ltd.
Contact:+86-13511538872
Address:Blk 43,Greenland Century Town,Huaian District, Huaian City,Jiangsu Province,China
Geen Chemical Technology Co., Ltd
Contact:86-769-21660847
Address:1408, Yingfeng Commercial Center, Nancheng District
Nanjing Spring & Autumn Biological Engineering Co., Ltd.
Contact:86-180510-83338
Address:Suite# 210, No. 1 BuildingNanjing Agricultural Biotechnology High-tech Entrepreneurship Center, No. 4 Tongwei Road, Xuanwu District, Nanjing,China
Doi:10.1016/j.tetlet.2008.10.064
(2008)Doi:10.1021/jo00230a026
(1987)Doi:10.1021/ol802562b
(2009)Doi:10.1016/j.tetlet.2015.08.025
(2015)Doi:10.1021/jm00393a024
(1987)Doi:10.1134/s1070428008020097
(2008)
