ASYMMETRIC SYNTHESIS OF (R)-(+)-ETHYLMETHYL-n-PROPYLCARBINOL IN HIGH ENANTIOMERIC PURITY. A 1,3-OXATHIANE DERIVED FROM (+)-PULEGONE AS CHIRAL ADJUVANT

Article abstract of DOI:10.1016/S0040-4039(01)81768-8

A chiral, conformationally locked 1,3-oxathiane has been prepared by 1,4-addition of benzyl mercaptan to (+)-pulegone followed by Na/NH3 reduction and condensation of the resulting hydroxythiol with paraformaldehyde.The utility of this chiral adjuvant is