Ring E analogs of methyllycaconitine (MLA) as novel nicotinic antagonists

DOI: 10.1016/S0960-894X(99)00378-9

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2263 - 2266 (1999)

Update date:2022-08-03

Topics: Phosphorylation Experimental terms Patch-clamp recording Radioligand Binding Assay

Authors:

Bergmeier, Stephen C.

Lapinsky, David J.

Free, R. Benjamin

McKay, Dennis B.

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Article abstract of DOI:10.1016/S0960-894X(99)00378-9

We have prepared ring E analogs of the diterpenoid alkaloid methyllycaconitine. These compounds have been assayed for nicotinic activity and were found to act as functional antagonists on adrenal nicotinic receptors.

Full text of DOI:10.1016/S0960-894X(99)00378-9

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