SYNTHESE ET ETUDE CONFORMATIONELLE PAR R.M.N.-13C DE β-NUCLEOSIDES PYRIMIDIQUES CONTENANT UNE OU DEUX SOUSUNITES HEXOPYRANOSYLES: APPLICATION A LA CONFORMATION DE L'ANTHELMYCINE

Article abstract of DOI:10.1016/S0008-6215(00)80522-4

Several new peracetylated pyrimidine N-1 nucleosides containing one two β-D-hexopyranosyl residues have been synthesized and their physical characteristics are reported.The conformation of these nucleosides has been investigated by highresolution 13C-n.m.r. analysis after deblocking.It was poddible to distinguish between the syn and anti rotamers of 3-β-D-glucopyranosyluracyl, and to establish the favored anti conformation in solution of the nucleoside disaccharide, antibiotic anthelmycin.