ANOMALOUS METALATION BEHAVIOR IN 1,3-OXAZOLES. ALKYLATION OF 2-METHYL-4-CARBOXYOXAZOLES VIA THE CORNFORTH INTERMEDIATE

DOI: 10.1016/S0040-4039(01)81853-0

Source and publish data:

Tetrahedron Letters p. 3163 - 3166 (1981)

Update date:2022-09-26

Topics:

Authors:

Meyers, A. I.

Lawson, John P.

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Article abstract of DOI:10.1016/S0040-4039(01)81853-0

Metalation of the methyl group in the title compound is accomplished through the open chain Cornforth precursor.This technique is necessary due to the preferred metalation of the 5-H proton in oxazoles.

Full text of DOI:10.1016/S0040-4039(01)81853-0

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