Journal of Medicinal Chemistry p. 446 - 451 (1982)
Update date:2022-08-02
Topics:
Walsh, David A.
Shamblee, Dwight A.
Welstead, William J.
Sancilio, Lawrence F.
Several substituted 2-aminophenylacetic acid derivatives were prepared and tested for in vitro prostaglandin synthetase inhibition and for in vivo antiinflammatory activity.The 2-amino substituent is beneficial to potency in the inhibition of prostaglandin synthetase for the 3-phenoxy, 4-phenyl, and 3-benzoyl series, but only 3-benzoyl series shows increased antiinflammatory potency in the in vivo assay.
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