Journal of Organic Chemistry p. 6528 - 6533 (1994)
Update date:2022-09-26
Topics: Regioselectivity NMR spectroscopy Stereochemistry Deprotonation Cyclization Alkene Workup Intramolecular Reaction Nucleophilic Attack Quenching Ring-closing reaction Gas chromatography (GC) Anionic Cyclization carbanion Organolithium reagent Low-temperature reaction Methoxy group (-OCH?)
Bailey, William F.
Jiang, Xing-Long
The cyclization of (4-methoxy-5-hexenyl)lithium (1), which was prepared by lithium-iodine exchange between 3-methoxy-6-iodo-1-hexene (2) and 1.75 molar equiv of t-BuLi in diethyl ether-n-pentane solution at -78 deg C, has been investigated in variety of solvent systems.The isomeric composition of the cis- and trans-1-methoxy-2-methylcyclopentane produced upon cyclization of 1 followed by quench with MeOH has been found to be dramatically dependent on the solvent system in which the isomerization is conducted.
View Morewebsite:http://www.biet.com.cn/
Contact:+86-27-8369 8488
Address:No. 6, Building 21, China Merchants Fanwang, Sixin North Road, Hanyang District, Wuhan City, Hubei Province
Chongqing Werlchem Fine Chemical Co. Ltd
Contact:+86-23-67521957
Address:NO.15,Fortune Road,Yubei District,401121,Chongqing,China
Shanghai Kangxin Chemical Co., Ltd
Contact:+86 21 60717227
Address:118,Ganbai Village,Waigang Town,Jiading District,Shanghai
Contact:0512-63006287
Address:no.88.YISHENG Road,etdz-WUJIANG,SUZHOU,CHINA
Hebei Kangtai Pharmaceutical Co.,Ltd
Contact:+86-0317-3512963
Address:Wugang Road,Mengcun of Cangzhou City,Hebei Province ,China
Doi:10.1021/ol010056d
(2001)Doi:10.1016/j.bmcl.2018.07.034
(2018)Doi:10.1016/S0008-6215(01)00088-X
(2001)Doi:10.1002/1099-0682(200106)2001:6<1613::AID-EJIC1613>3.0.CO;2-Z
(2001)Doi:10.1139/cjc-2020-0016
(2020)Doi:10.1107/S0108768100013197
(2001)
