Journal of Organic Chemistry p. 2810 - 2812 (1982)
Update date:2022-08-04
Topics:
Saulnier, Mark G.
Gribble, Gordon W.
A synthesis of the antitumor pyrido<4,3-b>carbazole alkaloid ellipticine (1a) is described in which the key steps are, successively, a highly regioselective acylation of 2-lithio-1-(phenylsulfonyl)indole (4) with 3,4-pyridinedicarboxylic anhydride (3) and acetic anhydride induced ring closure to give keto lactam 8.Further manipulation affords ellipticine in 54percent overall yield from indole (2a).
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Doi:10.1021/jo00185a022
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(1982)
