Journal of Organic Chemistry p. 2810 - 2812 (1982)
Update date:2022-08-04
Topics:
Saulnier, Mark G.
Gribble, Gordon W.
A synthesis of the antitumor pyrido<4,3-b>carbazole alkaloid ellipticine (1a) is described in which the key steps are, successively, a highly regioselective acylation of 2-lithio-1-(phenylsulfonyl)indole (4) with 3,4-pyridinedicarboxylic anhydride (3) and acetic anhydride induced ring closure to give keto lactam 8.Further manipulation affords ellipticine in 54percent overall yield from indole (2a).
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Doi:10.1021/jo00185a022
(1984)Doi:10.1002/1521-3765(20000804)6:15<2809::AID-CHEM2809>3.0.CO;2-M
(2000)Doi:10.1021/jo00150a015
(1983)Doi:10.1080/10426507.2018.1539848
(2019)Doi:10.1002/ejic.201000150
(2010)Doi:10.1135/cccc19820630
(1982)
