An Efficient Total Synthesis of (+/-)-Aklavinone

DOI: 10.1021/ja00381a017

Source and publish data:

Journal of the American Chemical Society p. 4604 - 4610 (1982)

Update date:2022-08-03

Topics:

Authors:

Boeckman, Robert K.

Sum, F.-W.

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Article abstract of DOI:10.1021/ja00381a017

An 11-step total synthesis of (+/-)-aklavinone from 1,3-cyclohexadione is reported.The key steps include a Diels-Alder condensation of 3 and 4 and the stereoselective aldol condensation of 21 to 22.The overall yield is ca. 13percent.

Full text of DOI:10.1021/ja00381a017

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