STEREOSELECTIVE SYNTHESIS OF (2S,3S,4R)-4-AMINO-3-HYDROXY-2-METHYL-PENTANOIC ACID, AN AMINO ACID CONSTITUENT OF BLEOMYCIN, BY ALDOL CONDENSATION

Article abstract of DOI:10.1016/S0040-4039(00)86879-3

(2S,3S,4R)-4-Amino-3-hydroxy-2-methylpentanoic acid, a novel amino acid constituent of bleomycin, has been synthesized stereoselectively through aldol condensation of (R)-2-aminopropionaldehyde derivatives and E-vinyloxyboranes.