STEREOSELECTIVE SYNTHESIS OF (2S,3S,4R)-4-AMINO-3-HYDROXY-2-METHYL-PENTANOIC ACID, AN AMINO ACID CONSTITUENT OF BLEOMYCIN, BY ALDOL CONDENSATION

DOI: 10.1016/S0040-4039(00)86879-3

Source and publish data:

Tetrahedron Letters p. 525 - 528 (1982)

Update date:2022-07-30

Topics:

Authors:

Narita, Masatoshi

Otsuka, Masami

Kobayashi, Susumu

Ohno, Masaji

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Article abstract of DOI:10.1016/S0040-4039(00)86879-3

(2S,3S,4R)-4-Amino-3-hydroxy-2-methylpentanoic acid, a novel amino acid constituent of bleomycin, has been synthesized stereoselectively through aldol condensation of (R)-2-aminopropionaldehyde derivatives and E-vinyloxyboranes.

Full text of DOI:10.1016/S0040-4039(00)86879-3

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Product name:(R)-4-Benzyloxycarbonylamino-3-hydroxy-2-methyl-pentanethioic acid S-phenyl ester

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