Journal of Medicinal Chemistry p. 1408 - 1412 (1982)
Update date:2022-08-05
Topics: Lipophilicity Nuclear magnetic resonance (NMR) spectroscopy Enantioselectivity Mass spectrometry (MS) IC50 High-performance liquid chromatography (HPLC) In Vivo Studies Structure-Activity Relationship (SAR) Pharmacokinetics Bioavailability Dose-Response Curve In Vitro Studies Ester Hydrolysis (Aryloxy)propanolamines Half-life (t?) β-Adrenergic receptors
Erhardt, Paul W.
Woo, Chi M.
Anderson, William G.
Gorczynski, Richard J.
Several short-acting β-adrenergic receptor blocking agents have been prepared by incorporating ester functions into the aryl portion of certain (aryloxy)propanolamine systems.In particular, methyl 3-<4-<2-hydroxy-3-(isopropylamino)propoxy>phenyl>propionate hydrochloride (ASL-8052) was found to be a moderately potent, cardioselective compound with a short duration of action when determined in in vivo canine models.
View MoreHangzhou Mole's Science & Technology Co.,Ltd.(expird)
Contact:+86-571-56880228
Address:15F Guodu development Building, NO.182 Zhaohui Road
KAIYUAN CHEMICAL COMPANY LIMITED.
website:http://www.kaiyuanchem.com
Contact:+86-22-59891255/66/77
Address:B-2205, Kuangshi International Building, Yingbin Road, XiangLuo Bay Business District, Binhai New area, Tianjin, China.
Shanghai Yuantai Chemical Products Co., Ltd
Contact:021--66129803
Address:Chengyin Road,Shanghai,China
Contact:86-371-63655023
Address:No.85,jinshui road,zhengzhou,China
Lyrin Industrial Corporation Limited
Contact:86-731-82571800
Address:Rm 2408,Asia Economy International Building,Shaoshan Road South,Yuhua District,Changsha,Hunan,China
Doi:10.1021/ol048054r
(2005)Doi:10.1016/S0040-4039(00)87532-2
(1982)Doi:10.1248/cpb.28.2580
(1980)Doi:10.1016/S0040-4039(00)87459-6
(1982)Doi:10.1021/ja00390a008
(1982)Doi:10.1021/jo00148a034
(1982)
