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Synthesis of Tetranuclear Iron-Sulphur Protein Analogues with Tetrathiol Ligands attached to Macrocycles which provide Intramolecular Hydrophobic Domains

DOI: 10.1039/DT9900003375

Source and publish data:

Journal of the Chemical Society, Dalton Transactions p. 3375 - 3381 (1990)

Update date:2022-08-05

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Authors:

Okuno, Hiroaki (Yohmei)Okuno, Hiroaki (Yohmei)

Uoto, KouichiUoto, Kouichi

Tomohiro, TakenoriTomohiro, Takenori

Youinou, Marie-ThereseYouinou, Marie-Therese

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Article abstract of DOI:10.1039/DT9900003375

A new type of active-site analogues for 4Fe-4S iron-sulphur proteins is introduced, where the active site core is surrounded by an intramolecular hydrophobic domain formed by a 36-membered ring consisting of a methylene backbone.An efficient synthesis of the macrocyclic ligands 1,10,19,28-tetra(4-mercaptobenzoyl)-1,10,19,28-tetra-azacyclohexatriacontane and 1,10,19,28-<4-(mercaptomethyl)benzoyl>-1,10,19,28-tetra-azacyclohexatriacontane and 1,10,19,28-tetra-(3-mercapto-3-methylbutanoyl)-1,10,19,28-tetra-azacyclohexatriacontane is described.Their reaction with t)4>2- afforded novel clusters in good yields (70 - 90percent) as black powders with m.p. > 300 deg C.They dissolve in dimethylformamide, dimethyl sulphoxide, and propylene carbonate.Complex formation with Fe4S4 clusters was mainly demonstrated by u.v.-visible and n.m.r. studies and the properties of the new clusters are discussed.

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