Angewandte Chemie - International Edition p. 12960 - 12965 (2014)
Update date:2022-08-02
Topics:
Eirich, Jürgen
Braig, Simone
Schyschka, Liliana
Servatius, Phil
Hoffmann, Judith
Hecht, Sabrina
Fulda, Simone
Zahler, Stefan
Antes, Iris
Kazmaier, Uli
Sieber, Stephan A.
Vollmar, Angelika M.
Resistance to chemotherapeutic agents represents a major challenge in cancer research. One approach to this problem is combination therapy, the application of a toxic chemotherapeutic drug together with a sensitizing compound that addresses the vulnerability of cancer cells to induce apoptosis. Here we report the discovery of a new compound class (T8) that sensitizes various cancer cells towards etoposide treatment at subtoxic concentrations. Proteomic analysis revealed protein disulfide isomerase (PDI) as the target of the T8 class. In-depth chemical and biological studies such as the synthesis of optimized compounds, molecular docking analyses, cellular imaging, and apoptosis assays confirmed the unique mode of action through reversible PDI inhibition. In the battle against the chemoresistance of cancer cells a screening approach has identified a novel compound class that sensitizes cancer cells in combination with etoposide. Proteomic target discovery revealed the reversible inhibition of protein disulfide isomerase as the molecular mechanism, which was further supported by cellular imaging studies and docking and biochemical assays in various cancer model systems.
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