ASYMMETRIC CONJUGATE ADDITION OF COPPER AZAENOLATES AS SYNTHETIC EQUIVALENT OF ENOLATES TO CYCLIC ENONES

Article abstract of DOI:10.1016/S0040-4039(00)88664-5

Asymmetric conjugate addition to prochiral cyclic enones was devised by using copper azaenolates derived from an acetone imine of optically active amino ethers which were prepared from α-amino acids, the optical yields of the resulting 3-acetonylcycloalkanones being found to attain as high as 75percent e.e.