Synthesis and antihypertensive activity of 4'-substituted spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-ones

DOI: 10.1021/jm00359a007

Source and publish data:

Journal of Medicinal Chemistry p. 657 - 661 (1983)

Update date:2022-09-26

Topics:

Authors:

Clark Clark

Caroon Caroon

Kluge Kluge

Repke Repke

Roszkowski

Strosberg

Baker Baker

Bitter Bitter

Okada Okada

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Article abstract of DOI:10.1021/jm00359a007

A series of 4'-substituted spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-ones was prepared and evaluated for antihypertensive activity in the spontaneously hypertensive rat (SHR). The basic ring system was prepared in one step by condensation of dilithia

Full text of DOI:10.1021/jm00359a007

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