Synthesis and antihypertensive activity of 4'-substituted spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-ones

DOI: 10.1021/jm00359a007

Source and publish data:

Journal of Medicinal Chemistry p. 657 - 661 (1983)

Update date:2022-09-26

Topics:

Authors:

Clark Clark

Caroon Caroon

Kluge Kluge

Repke Repke

Roszkowski

Strosberg

Baker Baker

Bitter Bitter

Okada Okada

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00359a007

A series of 4'-substituted spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-ones was prepared and evaluated for antihypertensive activity in the spontaneously hypertensive rat (SHR). The basic ring system was prepared in one step by condensation of dilithia

Full text of DOI:10.1021/jm00359a007

Products guided by the article

Product name:1-METHYLSPIRO[4H-3,1-BENZOXAZINE-4,4'-PIPERIDIN]-2(1H)-ONE

Cas No:84060-10-6

R&D Labs maybe for 84060-10-6

Weifang Arylchem Chemical Co., LTD

Contact:86-536-5217866

Address:Development Zone, Shouguang, Shandong Province
xujianqiang

Contact:86-21-57725962

Address:shanghai
Shanghai Apeptide Co., Ltd.

website:http://www.apeptides.com/en/

Contact:+86-21-60871011

Address:No. 80 Chuanshan Shuyuan Steet,Pudong,Shanghai
Beijing eternalchem Co,. Ltd

Contact:+86-10-59484199

Address:No.58-A1026 Liangguan Street
HUNAN CHEMAPI BIOLOGICAL TECHNOLOGY CO.,LTD.

Contact:+86-186-02659358

Address:1004, building 3, Wanke Jinsemaitianyuan, 498 Guitang Road, Yuhua District, Changsha City, Hunan Province, China

Relevant to this article

Visible-light-driven external-photocatalyst-free alkylative carboxylation of alkenes with CO₂

Doi:10.1007/s11426-021-1004-y
(2021)
Evaluation of the 2-substituent effect on the reactivity of the 8-haloimidazo[1,2-α]pyridine series towards Suzuki-type cross-coupling reaction

Doi:10.1246/bcsj.78.154
(2005)
Synthesis and characterization of rare earth complexes with benzene-1,3,5-tricarboxylic acid

Doi:10.1080/00945719809349414
(1998)
Discovery of novel N-benzylbenzamide derivatives as tubulin polymerization inhibitors with potent antitumor activities

Doi:10.1016/j.ejmech.2021.113316
(2021)
Design at the atomic level: Design of biaryloxazolidinones as potent orally active antibiotics

Doi:10.1016/j.bmcl.2008.10.011
(2008)
Studies of non-nucleoside HIV-1 reverse transcriptase inhibitors. Part 2: Synthesis and structure-activity relationships of 2-cyano and 2-hydroxy thiazolidenebenzenesulfonamide derivatives

Doi:10.1016/j.bmc.2004.11.045
(2005)

Article Doi