Minor structural modifications convert the dual TP/CRTH2 antagonist ramatroban into a highly selective and potent CRTH2 antagonist

Article abstract of DOI:10.1021/jm049036i

Ramatroban, a thromboxane A₂ receptor (TP) antagonist with clinical efficacy in asthma and allergic rhinitis, was recently shown to also antagonize the prostaglandin D₂ receptor CRTH2. Here we report that minor structural changes to