Facile Synthesis of Benzimidazol-2-one Derivatives by Modified Lossen Rearrangement

Article abstract of DOI:10.1021/je00032a042

A "formamide modification" has been applied to the Lossen rearrangement of several biologically important anthranilohydroxamic acids, some of them prepared for the first time.It has been found that a short heating at temperatures in the range 130-140 deg C converts these compounds into corresponding benzimidazol-2-ones with excellent yields.