Tetrahedron Letters p. 2547 - 2550 (1985)
Update date:2022-09-26
Topics:
Katti, S. B.
Agarwal, K. L.
Use of a novel coupling reagent, N,N-bis<2-oxo-3-oxazolidinyl>phosphorodiamidic chloride (BOPDC) in the synthesis of oligodeoxyribonucleotides is described.This reagent allows the synthesis of phosphotriesters in high yields (70-80 percent) without detectable side reactions.Synthesis of a hexanucleotide, d(A-A-C-C-C-G) is presented as an example.
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