Angiotensin-converting enzyme inhibitors: Synthesis and biological activity of acyl tripeptide analogues of enalapril

DOI: 10.1021/jm00382a008

Source and publish data:

Journal of Medicinal Chemistry p. 434 - 442 (1985)

Update date:2022-08-05

Topics: Synthesis High-performance liquid chromatography (HPLC) Analogues Biological Activity Synthesis reaction Angiotensin-converting enzyme inhibitors

Authors:

Greenlee

Allibone

Perlow Perlow

Patchett

Ulm Ulm

Vassil Vassil

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Article abstract of DOI:10.1021/jm00382a008

The synthesis and biological activity of a series of inhibitors of angiotensin-converting enzyme (EC 3.4.15.1) are described. Incorporation of the substituted N-carboxymethyl dipeptide design of enalapril (MK-421) into acyl tripeptides and larger peptides

Full text of DOI:10.1021/jm00382a008

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