A FACILE SYNTHESIS OF PRIMARY AMINES FROM CARBOXYLIC ACIDS BY THE CURTIUS REARRANGEMENT

Article abstract of DOI:10.1016/S0040-4039(01)91063-9

2-Trimethylsilylethanol was used to trap isocyanates produced by the Curtius rearrangement of acyl azides and the resulting trimethylsilylethyl carbamates were readily cleaved with tetra-n-butylammonium fluoride to liberate the primary amines.