Antihypertensive β-adrenergic blocking agents: N-aralkyl analogues of 2-[3-(tert-butylamino)-2-hydroxypropoxy]-3-cyanopyridine

DOI: 10.1021/jm00359a006

Source and publish data:

Journal of Medicinal Chemistry p. 649 - 657 (1983)

Update date:2022-08-05

Topics:

Authors:

McClure McClure

Baldwin Baldwin

Randall Randall

Lyon Lyon

Mensler Mensler

Lundell Lundell

Raab Raab

Gross Gross

Risley Risley

Sweet Sweet

Williams

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00359a006

An interest in dual-acting antihypertensive agents, specifically those related to (S)-2-[3-(tert-butylamino)-2-hydroxypropoxy]-3-cyanopyridine (1), led us to probe the contribution of the side-chain amino substituent in this series. The ability of 1 and i

Full text of DOI:10.1021/jm00359a006

Products guided by the article

Product name:2-{2-Hydroxy-3-[3-(4-methoxy-phenyl)-1-methyl-propylamino]-propoxy}-nicotinonitrile

Cas No:84945-84-6

R&D Labs maybe for 84945-84-6

Anhui Jiatiansen Agrochemical Co.,Ltd

Contact:15366811918

Address:chemical industrial park,xiangyu town,dongzhi county,anhui,china
Pengchen New Material Technology Co., Ltd.

Contact:+86-512-63680537

Address:99.6 km of national road 318, Meiyan Community,Pingwang Town, Wujiang District, Suzhou 215225
Zhejiang Linhai Xinhua Chemicals Factory

Contact:0086-13661858911

Address:Xunqiao Development Zone, Linhai, Zhejiang, China
Langchem

Contact:+86+21-58956006 15800617331

Address:402 Room, 150# Cailun Road, Zhangjiang high tech park, Shanghai
Jinan Trio PharmaTech Co., Ltd

Contact:86-531-88811783；+(0)13153010282

Address:2766 Yingxiu Road, Jinan High-Tech Zone, China

Relevant to this article

Lead Optimization of Benzoxepin-Type Selective Estrogen Receptor (ER) Modulators and Downregulators with Subtype-Specific ERα and ERβ Activity

Doi:10.1021/acs.jmedchem.6b01917
(2018)
An easy transformation of 2-amino-2-(hydroxyimino)acetates to carbamoylformamidoximes

Doi:10.1055/s-2004-837285
(2005)
Conversions of N-Vinylpyridinium Cations into Tricyclic Cage Compounds

Doi:10.1021/jo00177a013
(1984)
Bi(OTf)₃-catalyzed tandem Meyer-Schuster rearrangement and 1,4-addition to the resulting vinyl ketone

Doi:10.1021/jo5017663
(2014)
Direct organocatalytic asymmetric α-oxidation of ketones with iodosobenzene and N-sulfonyloxaziridines

Doi:10.1016/j.tetlet.2005.01.167
(2005)
Condensation products of 1-aryl-3-ethoxycarbonyl-2-methyl-1,4,5,6- tetrahydro-4(1H)pyridones with hydrazine, phenylhydrazine, and hydroxylamine

Doi:10.1023/B:COHC.0000040773.29086.36
(2004)

Article Doi