REACTION OF TRIMETHYLSILYL ENOL ETHERS WITH ISOQUINOLINIUM SALTS. A FACILE SYNTHESIS OF ETHYL 1-(2-OXOALKYL)-1,2-DIHYDROISOQUINOLINE-2-CARBOXYLATES AND THEIR CYCLIZATION

Article abstract of DOI:10.1246/cl.1983.39

An efficient method is described for the synthesis of ethyl 1-(2-oxoalkyl)-1,2-dihydroisoquinoline-2-carboxylates by C-C bond formation between 2-ethoxycarbonylisoquinolinium chloride and trimethylsilyl enol ethers.The products were treated with a few bases to afford the corresponding pyrido<2,1-a>isoquinoline derivatives.