Archiv der Pharmazie p. 229 - 236 (1983)
Update date:2022-08-05
Topics:
Moehrle, Hans
Miller, Christoph
Various p-substituted phenolic Mannich bases (and to a minor degree o-substituted derivatives) form alcohols and ethers when heated in aqueous alcohols in the presence of Na2EDTA or acetic acid.The reaction proceeds with amine elimination and subsequent addition of the solvent to the resulting quinone methide.
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Doi:10.1002/hlca.19470300304
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