Archiv der Pharmazie p. 385 - 394 (1983)
Update date:2022-08-05
Topics:
Koch
Tscherny
Zinsberger
The kinetics of the hydrolysis of silybin dihemisuccinate at various pH values were investigated. The ester group is not hydrolized in acidic or neutral media. In alkaline solutions, the rate of hydrolysis increases linearly with increasing pH. An HPLC method for the quantitative determination of silybin, its dihemisuccinate, and of two isometric monohemisuccinates is reported.
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