A New Colorimetric Protecting Group Allowing Deprotection Under Neutral Conditions

Article abstract of DOI:10.1016/0040-4020(95)00228-Z

A 4',4'-dimethoxytrityl derivative of the levulinyl group has been developed for protection of nucleophilic functionalities such as hydroxyl groups by reaction of its symmetrical anhydride.It can rapidly be removed under mild conditions using a hydrazine-pyridinium acetate based buffer at near neutral pH.This protecting group can be detected with high sensitivity at 513 nm (ε=78,600).