Chemo-enzymatic synthesis of (R)-and (S)-2-hydroxy-4-phenylbutanoic acid via enantio-complementary deracemization of (±)-2-hydroxy-4-phenyl-3- butenoic acid using a racemase-lipase two-enzyme system

Article abstract of DOI:10.1055/s-2005-871577

Deracemization of (±)-2-hydroxy-4-phenylbut-3-enoic acid was accomplished by lipase-catalyzed kinetic resolution coupled to mandelate racemase-mediated racemization of the non-reacting substrate enantiomer. Stepwise cyclic repetition of this sequence led