Stereoselective syntheses of highly functionalized bicyclo[3.1.0]hexanes: A general methodology for the synthesis of potent and selective mGluR2/3 agonists

DOI: 10.1021/jo0511187

Source and publish data:

Journal of Organic Chemistry p. 8027 - 8034 (2005)

Update date:2022-08-05

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Authors:

Tan, Lushi

Yasuda, Nobuyoshi

Yoshikawa, Naoki

Hartner, Frederick W.

Eng, Kan Kaung

Leonard, William R.

Tsay, Fuh-Rong

Volante, Ralph P.

Tillyer, Richard D.

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Article abstract of DOI:10.1021/jo0511187

A Et₃Al mediated intramolecular epoxide opening, cyclopropanation reaction is described. The transformation provided highly functionalized bicyclo[3.1.0]hexane systems in high efficiency and with perfect H or F endo selectivity. Application of

Full text of DOI:10.1021/jo0511187

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