Journal of Medicinal Chemistry p. 1729 - 1732 (1983)
Update date:2022-08-05
Topics:
Hiebert, C. K.
Kopp, W. C.
Richerson, H. B.
Barfknecht, C. F.
A fluorescent-labeled muramyl dipeptide (MDP) has been prepared to probe immunoadjuvant cellular interactions.N-Acetylmuramyl-L-alanyl-D-isoglutamine (1) was synthesized in improved yield and reacted with 2-(fluoroesceinylamino)-4,6-dichloro-s-triazine (DTAF,2) to give the fluorescent adduct DTAF-MDP (3), attached through the 6-position of the sugar moiety.Adjuvant activity was assessed by using two different in vitro assays, macrophage spreading, and inhibition of macrophage migration.Both assays indicated that the apparent adjuvant activity of 3 is comparable to that of 1.
View Morewebsite:http://www.afinechem.com
Contact:+86-571-85134551
Address:No. 206 Zhen Hua Road, Hangzhou 310030, Zhejiang, China
changsha chenjin chemical technology co.,LtD(expird)
Contact:86-731-84451263
Address:Room 201/217-218, 101 Jingyuan Electronic Technology Co.,Ltd. Testing Center, No.69, Lufeng Road, High-tech Development Zone, Changsha, China
Contact:+86-579-85206992
Address:No 451 chouzhou north road ,room 1106 int'l business center , yiwu ,china
SHANGHAI RC CHEMICALS CO.,LTD.
website:http://www.rcc.net.cn
Contact:+86-21-50322175
Address:Rm1415 Yinqiao Masion No.58 Jinxin Road Pudong Shanghai China
Shao Xing Empire Import&Export CO.,ltd
Contact:86-575-82127757
Address:11#, Weiwu Road, Shangyu Industrial Park, Hangzhou Bay, Hangzhou, Zhejiang Province, China
Doi:10.1016/j.tetlet.2007.09.105
(2007)Doi:10.1021/acs.orglett.1c02093
(2021)Doi:10.1107/S0108270105025734
(2005)Doi:10.1039/jr9500002158
(1950)Doi:10.1016/S0277-5387(00)81532-6
(1983)Doi:10.1002/hlca.193802101154
(1938)
