Journal of Medicinal Chemistry p. 1729 - 1732 (1983)
Update date:2022-08-05
Topics:
Hiebert, C. K.
Kopp, W. C.
Richerson, H. B.
Barfknecht, C. F.
A fluorescent-labeled muramyl dipeptide (MDP) has been prepared to probe immunoadjuvant cellular interactions.N-Acetylmuramyl-L-alanyl-D-isoglutamine (1) was synthesized in improved yield and reacted with 2-(fluoroesceinylamino)-4,6-dichloro-s-triazine (DTAF,2) to give the fluorescent adduct DTAF-MDP (3), attached through the 6-position of the sugar moiety.Adjuvant activity was assessed by using two different in vitro assays, macrophage spreading, and inhibition of macrophage migration.Both assays indicated that the apparent adjuvant activity of 3 is comparable to that of 1.
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