LIPASE-CATALYSED KINETIC RESOLUTION OF N,O-DIACETYL-2-AMINO-1-BUTANOL IN DIISOPROPYL ETHER

Article abstract of DOI:10.1016/0957-4166(90)80006-K

N,O-Diacetyl-2-amino-1-butanol (2) on lipase-catalysed transesterification with 1-butanol in diisopropyl ether gave (S)-(-)-2 and (R)-(+)-N-acetyl-2-amino-1-butanol (3); proper stereochemistry and correct optical rotations of chiral 2 and 3, incorrectly reported in literature, were determined after their conversion to chiral 2-amino-1-butanol (1).