Tetrahedron p. 4667 - 4680 (1985)
Update date:2022-09-26
Royen, Luc A. Van
Mijngheer, Roelant
Clercq, Pierre J. De
A novel D <*> BCD <*> ABCD route to 11-keto steroids is reported involving a high yield stereoselective intramolecular Diels-Alder reaction of furan-diene 12 in water as a key-step.The dienophilic side chain is readily introduced starting from 8 via a sequence involving alkylation with ethyl (E)-3-ethoxy-4-iodo-2-butenoate, reduction and acid hydrolysis.The reduced adduct 14 is further converted into (+/-)-adrenosterone (6) via 24, the dienediolate equivalent of which is a known intermediate in corticosteroid synthesis.
View MoreContact:+86 512 6287 2180
Address:398 Ruoshui Road, Suzhou Industrial Park, Suzhou, Jiangsu, P. R. China
Contact:86-27-84888681
Address:Wuhan economic & technology development zone
jiangsu haian chemical co.,ltd.
Contact:86-513-15851283853
Address:No.99,Changjiang West Road,Haian County,Jiangsu Province,China
Shenzhen Feiming Science and Technology Co,. Ltd
Contact:+86-755-85232577
Address:#B2309, Fenglin International Center ,Jixiang Road, Longcheng street, LongGang District, Shenzhen city, Guangdong province, China.
Contact:86-10-62983737; +86-10-51287608
Address:4/F Building C, 2 Shangdi Xinxi Road
Doi:10.1081/NCN-200060271
(2005)Doi:10.1021/acs.orglett.9b02592
(2019)Doi:10.1021/ja00313a029
(1984)Doi:10.3109/14756366.2011.645241
(2013)Doi:10.1002/hlca.19830660516
(1983)Doi:10.1007/s10593-005-0125-4
(2005)
