Journal of Medicinal Chemistry p. 129 - 143 (1984)
Update date:2022-08-03
Topics:
Hansch
Hathaway
Guo
et al.
The inhibition of dihydrofolate reductase fron chicken liver and from Lactobacillus casei has been studied with 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(substituted-phenyl)-s-triazines. It was found that for the chicken enzyme, inhibitor potency for 101 triazines was correlated by a given equation. The mathematical models obtained from correlation analysis are compared with stereo color graphics models.
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(1984)
