Journal of Medicinal Chemistry p. 212 - 216 (1984)
Update date:2022-07-31
Topics:
Terada, Atsusuke
Naruto, Shunji
Wachi, Kazuyuki
Tanaka, Shigeru
Iizuka, Yoshio
Misaka, Eiichi
<(Cycloalkylmethyl)phenyl>acetic acid derivatives and related compounds were synthesized to test their antiinflammatory and analgesic activities.Some of the compounds in this series were found to have good activity in the carrageenan edema test.Among them, sodium 2-<4-<(2-oxocyclopentyl)methyl>phenyl>propionate dihydrate (15) and 2-<4-<(2-oxocyclohexylidene)methyl>phenyl>propionic acid (13b) showed potent analgesic and antiadjuvant arthritis activities with excellent antipyretic properties.
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