Synthesis and Antiinflammatory Activity of acetic Acids and Related Compounds

DOI: 10.1021/jm00368a019

Source and publish data:

Journal of Medicinal Chemistry p. 212 - 216 (1984)

Update date:2022-07-31

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Authors:

Terada, Atsusuke

Naruto, Shunji

Wachi, Kazuyuki

Tanaka, Shigeru

Iizuka, Yoshio

Misaka, Eiichi

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Article abstract of DOI:10.1021/jm00368a019

<(Cycloalkylmethyl)phenyl>acetic acid derivatives and related compounds were synthesized to test their antiinflammatory and analgesic activities.Some of the compounds in this series were found to have good activity in the carrageenan edema test.Among them, sodium 2-<4-<(2-oxocyclopentyl)methyl>phenyl>propionate dihydrate (15) and 2-<4-<(2-oxocyclohexylidene)methyl>phenyl>propionic acid (13b) showed potent analgesic and antiadjuvant arthritis activities with excellent antipyretic properties.

Full text of DOI:10.1021/jm00368a019

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