
Tetrahedron Letters p. 2529 - 2530 (1995)
Update date:2022-08-02
Topics:
Tsunoda, Tetsuto
Four secondary alcohols of different steric environment reacted with five carboxylic acids of different acidity in the presence of N,N,N′,N′-tetramethylazodicarboxamide and tributylphosphine to give the corresponding epi-esters in better yield than with diethyl azodicarboxylate-triphenylphosphine in most cases. Of special merit is the combination of the new reagent system with p-methoxybenzoic acid to achieve complete inversion of sterically congested secondary alcohols.
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