N6(N-METHYL-2-PYRROLIDINE AMIDINE)DEOXYADENOSINE - A NEW DEOXYNUCLEOSINE PROTECTING GROUP

DOI: 10.1016/S0040-4039(00)88067-3

Source and publish data:

Tetrahedron Letters p. 2953 - 2956 (1983)

Update date:2022-08-05

Topics:

Authors:

McBride, L. J.

Caruthers, M. N.

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Article abstract of DOI:10.1016/S0040-4039(00)88067-3

The synthesis and characterization of N⁶(N-methyl-2-pyrrolidine amidine) 2'-deoxyadenosine is described.This amidine is significantly more stable toward acid catalyzed depurination than N-benzoyldeoxyadenosine, is easy to prepare and can be removed rapidly and quantitatively.

Full text of DOI:10.1016/S0040-4039(00)88067-3

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