α-ALKYLATION OF A CYSTEINE DERIVATIVE WITHOUT RACEMIZATION AND WITHOUT THE USE OF A CHIRAL AUXILIARY

Article abstract of DOI:10.1016/S0040-4039(00)86257-7

The (R,R)-2-t-butyl-1-aza-3-oxa-7-thia-bicyclo<3.3.0>octan-4-one (4a), obtained in two steps from cysteine, is added to aromatic aldehydes to give the diastereomerically and enantiomerically pure 5-(arylhydroxymethyl)-derivatives 6.